Synthesis and biological evalution of some thiazolidinone derivatives of acyclic and cyclic ketones as antibacterial agents

Thiosemicarbazone and 4-thiazolidinone derivatives were synthesized in one and two step, respectively from thiosemicarbazide, in satisfactory yields. The structure of the compounds were elucidated by Elemental, IR, and NMR spectral data. The antibacterial activity of these compounds was tested by disc diffusion assay against two Gram-positive and two Gram-negative bacterie. The results showed that acyclic and cyclic 4-thiazolidinone derivatives are better in inhibiting the growth of both types of bacteria. Compounds 4e and 7b were found to be most potent compared to standard drug Norfloxacin.